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butabarbital will reduce the level or influence of fedratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Result of coadministering a solid CYP3A4 inducer with fedratinib hasn't been researched.butabarbital will minimize the extent or impact of aprepitant by impacting hepatic/intestinal enzyme CYP3A4 metab